CCN3: Lactational Bone Booster and a Novel Brain-Bone Axis in Mammalian Mothers

This study identifies Cellular Communication Network Factor 3 (CCN3) as a hormone critical for bone health during lactation, derived from ARHERα/Kiss1 neurons. CCN3 enhances skeletal stem cell activity, bone remodeling, and progeny survival. Findings establish a novel brain-bone axis, offering insights into therapeutic approaches for lactational osteoporosis and maternal skeletal health.

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